HLA不匹配的嵌合双胞胎中的免疫耐受
Immunological tolerance in an HLA non-identical chimeric twin.
作者信息
Viëtor H E, Hamel B C, van Bree S P, van der Meer E M, Smeets D F, Otten B J, Holl R A, Claas F H
机构信息
Department of Human Genetics, University Hospital Nijmegen, Nijmegen, The Netherlands.
出版信息
Hum Immunol. 2000 Mar;61(3):190-2. doi: 10.1016/s0198-8859(99)00183-4.
Blood group chimeric twins offer a unique opportunity to study immunological tolerance in humans. Although this condition is not as rare as previously considered, detailed immunological studies of blood group chimeras are lacking. We describe here a case of secondary chimerism in a dizygotic twin of opposite gender. The karyotypes of the cultured fibroblast confirmed the sex of each twin, all cells in the boy were 46, XY and all cells in the girl were 46, XX. Molecular HLA typing on fibroblasts revealed HLA-DR, DQ and DP disparities between the two siblings. Mixed lymphocyte culture (MLC) revealed a mutual absence of alloreactivity.
血型嵌合双胞胎为研究人类免疫耐受提供了独特的机会。尽管这种情况并不像之前认为的那么罕见，但缺乏对血型嵌合体的详细免疫学研究。我们在此描述一例异性双卵双胞胎中的继发性嵌合病例。培养的成纤维细胞的核型确定了每个双胞胎的性别，男孩的所有细胞均为46, XY，女孩的所有细胞均为46, XX。对成纤维细胞进行的分子HLA分型显示，两兄妹之间存在HLA-DR、DQ和DP差异。混合淋巴细胞培养（MLC）显示相互之间不存在同种异体反应性。
Zotero 插件