奥氮平治疗神经性厌食症的病例报告。

Case reports of olanzapine treatment of anorexia nervosa.

作者信息

La Via M C, Gray N, Kaye W H

机构信息

Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.

出版信息

Int J Eat Disord. 2000 Apr;27(3):363-6. doi: 10.1002/(sici)1098-108x(200004)27:3<363::aid-eat16>3.0.co;2-5.

DOI:10.1002/(sici)1098-108x(200004)27:3<363::aid-eat16>3.0.co;2-5

PMID:10694725

Abstract

Two females with severe anorexia nervosa were treated with olanzapine in open trials. Olanzapine was tried because it has caused weight gain in other patient groups. Both anorexic patients had a chronic illness and had failed multiple other treatments. Olanzapine administration was associated with weight gain and maintenance as well as reduced agitation and resistance to treatment. These case histories support further exploration of this class of drugs in anorexia nervosa.

摘要

在开放性试验中，两名患有严重神经性厌食症的女性接受了奥氮平治疗。之所以试用奥氮平，是因为它在其他患者群体中曾导致体重增加。这两名厌食症患者都患有慢性病，且多种其他治疗均告失败。服用奥氮平与体重增加及维持体重相关，同时还能减少激动情绪和增强对治疗的依从性。这些病例报告支持在神经性厌食症中对这类药物进行进一步探索。