大鼠15号染色体标记与血压的连锁分析。

Linkage analysis for blood pressure with rat chromosome 15 markers.

作者信息

Deng A Y

机构信息

Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614-5804, USA.

出版信息

Folia Biol (Praha). 1998;44(2):45-8.

PMID:10730855

Abstract

A series of markers located across rat chromosome (Chr.) 15 was mapped and then systematically genotyped for cosegregation with blood pressure in an F2 population that originated from crosses of the Dahl salt-sensitive (S) rats with rats of the Wistar-Kyoto (WKY) strain, i.e., F2(S x WKY). Alleles for the markers centered around the locus for endothelin-receptor B (Ednrb) weakly cosegregated with blood pressure in the F2(S x WKY) population. Therefore, it appears highly unlikely that there is major blood pressure quantitative trait locus (QTL) on rat Chr. 15, which possesses a strong effect on blood pressure in the S rat. The Chr. 15 map will be useful for mapping genes and searching for QTL of other biological traits.

摘要

对位于大鼠15号染色体（Chr.）上的一系列标记进行了定位，然后在一个由达尔盐敏感（S）大鼠与Wistar-Kyoto（WKY）品系大鼠杂交产生的F2群体中，即F2（S×WKY），对这些标记进行系统基因分型，以确定其与血压的共分离情况。在F2（S×WKY）群体中，以内皮素受体B（Ednrb）基因座为中心的标记等位基因与血压的共分离较弱。因此，大鼠15号染色体上似乎极不可能存在对S大鼠血压有强烈影响的主要血压数量性状基因座（QTL）。15号染色体图谱将有助于绘制基因图谱和寻找其他生物学性状的QTL。