人类群体中Y染色体特异性YCAII、DYS19和YAP多态性的比较研究。

Y-chromosome specific YCAII, DYS19 and YAP polymorphisms in human populations: a comparative study.

作者信息

Quintana-Murci L, Semino O, Poloni E S, Liu A, Van Gijn M, Passarino G, Brega A, Nasidze I S, Maccioni L, Cossu G, al-Zahery N, Kidd J R, Kidd K K, Santachiara-Benerecetti A S

机构信息

Dipartimento di Genetica e Microbiologia, Università di Pavia, Italy.

出版信息

Ann Hum Genet. 1999 Mar;63(Pt 2):153-66. doi: 10.1046/j.1469-1809.1999.6320153.x.

DOI:10.1046/j.1469-1809.1999.6320153.x

PMID:10738527

Abstract

Two hypervariable Y-specific markers, the YCAII and DYS19 STRs, and the more stable Y Alu Polymorphism (YAP) have been analysed in about 1400 individuals of 21 different populations, mainly from Europe but also from the Middle East, Africa and Asia. On the basis of the frequency distributions of these three Y-markers we compare, using different statistical analyses, their power in detecting population genetic structure and in distinguishing closely related groups. The pattern of populations' genetic affinities inferred from the three markers considered altogether suggests a strong genetic structure that, with a few exceptions, broadly corresponds to the linguistic relatedness and/or geographic location of the sampled populations.

摘要

我们对两个高变Y特异性标记（YCAII和DYS19短串联重复序列）以及更稳定的Y铝多态性（YAP）进行了分析，样本来自21个不同群体的约1400个人，主要来自欧洲，但也有来自中东、非洲和亚洲的。基于这三个Y标记的频率分布，我们使用不同的统计分析方法，比较它们在检测群体遗传结构以及区分亲缘关系较近群体方面的能力。综合考虑这三个标记推断出的群体遗传亲和模式表明，存在一种强大的遗传结构，除了少数例外情况，这种结构大致与抽样群体的语言相关性和/或地理位置相对应。