Amos L A
MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK.
Curr Opin Struct Biol. 2000 Apr;10(2):236-41. doi: 10.1016/s0959-440x(00)00070-1.
A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted.
通过将电子晶体学解析出的微管蛋白高分辨率结构与低分辨率的完整微管图谱对接,已得出微管原子结构的良好近似值。现在可以预测与其他分子的一些结构相互作用,包括核苷酸、药物、驱动蛋白和微管相关蛋白。