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[银杏叶提取物(EGb 761)作为外源性抗氧化因子]

[Ginkgo biloba extract (EGb 761) as an antioxidant factor of exogenous origin].

作者信息

Butnaru M, Iacobovici A, Haulică I, Hefco V

机构信息

Disciplina de Fiziologie Animală, Universitatea Al.I. Cuza, Iaşi.

出版信息

Rev Med Chir Soc Med Nat Iasi. 1997 Jul-Dec;101(3-4):192-6.

Abstract

Extracted from Ginkgo biloba leaves, the EGb 761 has a great number of therapeutical properties and anti-stress effects, for example the antioxidant one. We estimated in our experiment the influence of a chronic treatment with EGb 761 on the concentration of the main product of lipidic degradation--malondialdehyde (MDA), in cerebral cortex, in diencephalon, thymus and gastric mucosa. The experiment was performed on Wistar rats, male, young. The MDA estimation was performed by the spectrocalorimetry. We have determined that the stress raised the MDA concentration in all examined structures with approximately 100% and 80% of animals manifested stress ulcer. The treatment with EGb 761 before a stress inhibits the post-stress growth of MDA concentration and the process of stress ulcer formation.

摘要

从银杏叶中提取的EGb 761具有多种治疗特性和抗应激作用,例如抗氧化作用。在我们的实验中,我们评估了EGb 761长期治疗对大脑皮层、间脑、胸腺和胃黏膜中脂质降解主要产物——丙二醛(MDA)浓度的影响。实验选用雄性幼年Wistar大鼠进行。通过分光量热法测定MDA含量。我们发现应激使所有检测结构中的MDA浓度升高了约100%,并且80%的动物出现了应激性溃疡。应激前用EGb 761治疗可抑制应激后MDA浓度的升高以及应激性溃疡的形成过程。

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