铁和锰向大脑转运的现有及新出现的机制。

Existing and emerging mechanisms for transport of iron and manganese to the brain.

作者信息

Malecki E A, Devenyi A G, Beard J L, Connor J R

机构信息

Department of Neuroscience and Anatomy, College of Medicine, Pennsylvania State University, Hershey 17033, USA.

出版信息

J Neurosci Res. 1999 Apr 15;56(2):113-22. doi: 10.1002/(SICI)1097-4547(19990415)56:2<113::AID-JNR1>3.0.CO;2-K.

DOI:10.1002/(SICI)1097-4547(19990415)56:2<113::AID-JNR1>3.0.CO;2-K

PMID:10777372

Abstract

The metals iron (Fe) and manganese (Mn) are essential for normal functioning of the brain. This review focuses on recent developments in the literature pertaining to Fe and Mn transport. These metals are treated together because they appear to share several transport mechanisms. In addition, several neurological diseases such as Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease are all associated with Fe mismanagement in the brain, particularly in the striatum and basal ganglia. Similarly, Mn accumulation in brain also appears to target the same brain regions. Therefore, stringent regulation of the concentration of these metals in the brain is essential. The homeostatic mechanisms for these metals must be understood in order to design neurotoxicity prevention strategies.

摘要

金属铁（Fe）和锰（Mn）对大脑的正常运作至关重要。本综述聚焦于近期文献中有关铁和锰转运的进展。将这两种金属放在一起探讨是因为它们似乎共享多种转运机制。此外，几种神经疾病，如阿尔茨海默病、帕金森病和亨廷顿病，都与大脑中铁管理不当有关，尤其是在纹状体和基底神经节。同样，大脑中锰的积累似乎也靶向相同的脑区。因此，严格调控大脑中这些金属的浓度至关重要。为了设计预防神经毒性的策略，必须了解这些金属的稳态机制。