Sporik R, Platts-Mills T A, Cogswell J J
Department of Paediatrics, Poole General Hospital, Dorset, UK.
Clin Exp Allergy. 1993 Sep;23(9):740-6. doi: 10.1111/j.1365-2222.1993.tb00361.x.
Eighty-two children admitted to hospital with exacerbations of asthma were studied to determine how many were exposed to house dust mites at the time of admission and displayed immediate hypersensitivity to house dust mites. The concentration of house dust mite allergen (Der p I) was measured in dust obtained from the child's mattress, bedroom floor and living room floor. Sixty-two (75%) children admitted had been exposed to > 10 microg Der p I/g. Sixty-seven (82%) children were sensitive to house dust mite (RAST > or = 1 +, or weal > or = 3 mm): 49 (60%) children were both exposed and sensitive. In contrast in a control group of 44 children, 31 (70%) (n.s.) were exposed to > 10 microg Der p I/g, 10 (23%) (P<0.001) were sensitive to house dust mite, and 7 (16%) (P<0.001) were both exposed and sensitive. Seventy-three homes were revisited 6 months after the child's initial admission. During the preceding month 14 children had been readmitted, 12 were fully investigated; of these 10 were both sensitive to house dust mite and still exposed to > 10 microg Der p I/g. In contrast, of the remaining 62 children who were not readmitted, only 19 were both sensitive and still exposed to > 10 microg Der p I/g (P<0.001). In conclusion, the majority of children admitted to hospital with exacerbations of asthma were exposed to house dust mite allergen and were house dust mite sensitive. Further the results suggest that continued exposure to higher concentrations of mite allergen may be associated with the risk of readmission.
对82名因哮喘加重而住院的儿童进行了研究，以确定入院时接触屋尘螨并对屋尘螨表现出速发型超敏反应的儿童数量。测定了从儿童床垫、卧室地板和客厅地板采集的灰尘中屋尘螨过敏原（Der p I）的浓度。62名（75%）入院儿童接触的Der p I>10微克/克。67名（82%）儿童对屋尘螨敏感（放射性过敏原吸附试验≥1 +，或风团≥3毫米）：49名（60%）儿童既接触又敏感。相比之下，在44名儿童的对照组中，31名（70%）（无统计学差异）接触的Der p I>10微克/克，10名（23%）（P<0.001）对屋尘螨敏感，7名（16%）（P<0.001）既接触又敏感。在儿童首次入院6个月后，对73户家庭进行了回访。在前一个月，14名儿童再次入院，12名接受了全面检查；其中10名既对屋尘螨敏感，且仍接触>10微克/克的Der p I。相比之下，在其余62名未再次入院的儿童中，只有19名既敏感且仍接触>10微克/克的Der p I（P<0.001）。总之，大多数因哮喘加重而住院的儿童接触了屋尘螨过敏原且对屋尘螨敏感。此外，结果表明持续接触较高浓度的螨过敏原可能与再次入院风险相关。
