阿片肽可阻止人类免疫缺陷病毒（HIV）的侵入。
Apelin peptides block the entry of human immunodeficiency virus (HIV).
作者信息
Zou M X, Liu H Y, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H
机构信息
Department of Molecular Physiology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
出版信息
FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3.
The orphan G protein-coupled receptor APJ has been shown to be a coreceptor for human and simian immunodeficiency virus (HIV and SIV) strains. We have determined that some HIV and SIV strains use APJ as a coreceptor to infect the brain-derived NP-2/CD4 cells. Because apelin is an endogenous ligand for the APJ receptor, we examined the inhibitory effects of apelin peptides on HIV infection, and found that the apelin peptides inhibit the entry of some HIV-1 and HIV-2 into the NP-2/CD4 cells expressing APJ. The inhibitory efficiency has been found to be in the order of apelin-36>apelin-17>apelin-13>apelin-12.
孤儿G蛋白偶联受体APJ已被证明是人类和猿猴免疫缺陷病毒（HIV和SIV）毒株的共受体。我们已经确定，一些HIV和SIV毒株利用APJ作为共受体来感染脑源性NP-2/CD4细胞。由于apelin是APJ受体的内源性配体，我们研究了apelin肽对HIV感染的抑制作用，发现apelin肽可抑制某些HIV-1和HIV-2进入表达APJ的NP-2/CD4细胞。已发现抑制效率的顺序为apelin-36>apelin-17>apelin-13>apelin-12。
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