T细胞介导的副肿瘤性神经炎——一例尸检病例

T cell-mediated paraneoplastic ganglionitis--an autopsy case.

作者信息

Drlicek M, Bodenteich A, Setinek U, Tucek G, Urbanits S, Grisold W

机构信息

Ludwig Boltzmann Institut für Neuroonkologie, Linz, Austria.

出版信息

Acta Neuropathol. 2000 May;99(5):599-602. doi: 10.1007/s004010051168.

DOI:10.1007/s004010051168

PMID:10805108

Abstract

A 57-year-old woman presented with subacute sensory, ataxic neuronopathy. Clinical investigation revealed a right-sided non-small-cell lung cancer. Serum investigation for specific antineuronal antibodies was negative. Histology showed T lymphocytic infiltrates in dorsal root ganglia. The observed histological pattern is similar to that described in antibody-positive cases. Thus, these findings suggest similar pathways in specific antineuronal antibody-negative and -positive cases of paraneoplastic subacute sensory neuronopathy.

摘要

一名57岁女性表现为亚急性感觉性共济失调性神经病。临床检查发现右侧非小细胞肺癌。血清特异性抗神经元抗体检测为阴性。组织学检查显示背根神经节有T淋巴细胞浸润。观察到的组织学模式与抗体阳性病例中描述的相似。因此，这些发现提示在副肿瘤性亚急性感觉神经元病的特异性抗神经元抗体阴性和阳性病例中存在相似的发病途径。