Adelman R D, Coppo R, Dillon M J
Department of Pediatrics, Eastern Virginia Medical School, Norfolk, USA.
Pediatr Nephrol. 2000 May;14(5):422-7. doi: 10.1007/s004670050787.
Severe hypertension in childhood is a life-threatening clinical problem that carries with it not only serious sequelae of inadequate treatment but equally serious complications of over enthusiastic therapy. The majority of cases have some form of underlying renal disease. Therapeutic success is achieved by slow and safe reduction of blood pressure with the immediate target of avoiding hypertensive sequelae yet allowing preservation of target organ function. Short-acting parenteral antihypertensives are recommended along with careful blood pressure monitoring to prevent complications arising through loss of autoregulatory control.
儿童重度高血压是一个危及生命的临床问题,不仅治疗不充分会带来严重后遗症,过度积极治疗同样会引发严重并发症。大多数病例都有某种形式的潜在肾脏疾病。治疗成功的关键在于缓慢而安全地降低血压,直接目标是避免高血压后遗症,同时保留靶器官功能。建议使用短效胃肠外抗高血压药物,并仔细监测血压,以防止因自动调节控制丧失而引发并发症。