Zhou J, Liu L, Chen Q
Department of Anesthesiology, Second Affiliated Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1998;23(6):572-4.
Effects of propofol(Group P) and etomidate(Group E) on cerebral oxygen supply and demand balance during middle hypothermia cardiopulmonary bypass(CPB) were studied in twenty patients undergoing cardiac valve replacement. Arterial blood and jugular bulb blood were taken to analyse blood gas, and cerebral oxygen content were caculated.
During hypothermia, jugular bulb oxygen saturation(SjO2), jugular bulb blood oxygen content(CjO2) increased; cerebral oxygen extraction rate(CEO2) decreased significantly in two groups(P < 0.05). During rewarming SjO2, CjO2 were significantly decreased, CEO2 increased compared with that before rewarming and hypothermia in two gbroups (P < 0.05). In Group P, SjO2 and CjO2 were higher, CEO2 lower than those in Group E respectively during rewarming (P < 0.05). CONCULUSION: The activity of propofol reduced cerebral metabolism, cerebral oxygen consumption and CEO2 is better than that of etomidate.
在20例接受心脏瓣膜置换术的患者中，研究了丙泊酚组（P组）和依托咪酯组（E组）在中度低温体外循环（CPB）期间对脑氧供需平衡的影响。采集动脉血和颈静脉球血分析血气，并计算脑氧含量。
低温期间，两组颈静脉球血氧饱和度（SjO2）、颈静脉球血氧含量（CjO2）升高；脑氧摄取率（CEO2）显著降低（P<0.05）。复温期间，两组SjO2、CjO2显著降低，CEO2较复温和低温前升高（P<0.05）。复温期间，P组SjO2和CjO2分别高于E组，CEO2低于E组（P<0.05）。结论：丙泊酚的活性降低了脑代谢，脑氧消耗，且其对CEO2的影响优于依托咪酯。
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