Desreumaux P, Wallaert B, Janin A
Clinique des maladies de l'appareil digestif, Hôpital Huriez, CHRU Lille.
Rev Prat. 2000 Mar 15;50(6):630-5.
Eosinophils are produced in the bone marrow and circulate in the peripheral blood in a quiescent state. After margination and emigration into tissues through postcapillary venules, eosinophils primarily reside in mucosal sites including the gastrointestinal and respiratory tracts. Eosinophilic gastroenteritis and the idiopathic chronic eosinophilic pneumonia, first described by Carrington, are the most characterized idiopathic diseases defined by an eosinophil infiltration restricted respectively to the gastrointestinal and the respiratory tracts. Differential diagnosis can be difficult since several disorders and particularly the idiopathic hypereosinophilic syndrome have many clinical, morphological and histological similarities.
嗜酸性粒细胞在骨髓中产生,并以静止状态在外周血中循环。在通过毛细血管后微静脉靠边并迁移到组织中后,嗜酸性粒细胞主要驻留在包括胃肠道和呼吸道在内的黏膜部位。嗜酸性粒细胞性胃肠炎和由卡林顿首次描述的特发性慢性嗜酸性粒细胞性肺炎,是分别由嗜酸性粒细胞浸润局限于胃肠道和呼吸道所定义的最具特征性的特发性疾病。鉴别诊断可能很困难,因为几种疾病,特别是特发性高嗜酸性粒细胞综合征,在临床、形态学和组织学上有许多相似之处。