通过在Cellogel上进行等电聚焦可检测到的磷酸葡萄糖变位酶基因座1的罕见表型。

Rare phenotypes of the phosphoglucomutase locus 1 detectable by isoelectric focusing on Cellogel.

作者信息

Dobosz T, Kozioł P

机构信息

Department of Forensic Medicine, Medical Academy, Wrocław, Poland.

出版信息

Hum Genet. 1981;59(1):81-3. doi: 10.1007/BF00278861.

DOI:10.1007/BF00278861

PMID:10819029

Abstract

The rare phenotypes PGM1, determined by alleles PGM1(3), PGM1(4), PGM1(6), and PGM1(7) were examined by starch gel electrophoresis and cellulose acetate gel isoelectric focusing and were compared with the commonest phenotypes of PGM1. The frequencies of the rare genes found in the Polish populations were as follows: in Lublin, PGM1(3) = 0.0002, PGM1(4) = 0.0005, PGM1(6) = 0.0010, and PGM1(7) = 0.0005; in Wrocław, PGM1(3) = 0.0000, PGM1(4) = 0.0005, PGM1(6) = 0.0007, and PGM1(7) = 0.0002. The results suggest that the F and S type variants of the genes PGM1(4) and PGM1(7) probably do not occur. It is still possible that F and S variants exist for the genes PGM1(3) and PGM1(6).

摘要

通过淀粉凝胶电泳和醋酸纤维素凝胶等电聚焦法检测了由等位基因PGM1(3)、PGM1(4)、PGM1(6)和PGM1(7)决定的罕见PGM1表型，并与最常见的PGM1表型进行了比较。在波兰人群中发现的罕见基因频率如下：在卢布林，PGM1(3)=0.0002，PGM1(4)=0.0005，PGM1(6)=0.0010，PGM1(7)=0.0005；在弗罗茨瓦夫，PGM1(3)=0.0000，PGM1(4)=0.0005，PGM1(6)=0.0007，PGM1(7)=0.0002。结果表明，PGM1(4)和PGM1(7)基因的F型和S型变体可能不存在。PGM1(3)和PGM1(6)基因仍有可能存在F型和S型变体。