因子VIII相关抗原：人血浆中的多种分子形式。

Zimmerman T S, Roberts J, Edgington T S

Proc Natl Acad Sci U S A. 1975 Dec;72(12):5121-5. doi: 10.1073/pnas.72.12.5121.

Analysis of Factor-VIII-related antigen (vWAg) in normal plasma by crossed immunoelectrophoresis reveals an asymmetric pattern indicative of molecular heterogeneity. This asymmetric pattern apparently results from the presence of multiple molecular forms of VWAg with distinct, though partially overlapping, mobilities on crossed immunoelectrophoresis. Evidence for this conclusion has been obtained by separating these forms, one from another, utilizing cryoprecipitation, agarose gel chromatography, and ion-exchange chromatography. Variation in the relative destribution of VWAg forms in liver disease and disseminated intravascular coagulation suggests that the processes which govern generation and/or breakdown of these forms can be altered by disease.

通过交叉免疫电泳分析正常血浆中的因子VIII相关抗原（vWAg），显示出一种不对称模式，表明分子具有异质性。这种不对称模式显然是由于存在多种分子形式的VWAg，它们在交叉免疫电泳上具有不同但部分重叠的迁移率。通过利用冷沉淀、琼脂糖凝胶色谱法和离子交换色谱法将这些形式彼此分离，已获得了这一结论的证据。在肝病和弥散性血管内凝血中VWAg形式的相对分布变化表明，控制这些形式产生和/或分解的过程可能会因疾病而改变。