微晶纤维素和硅化微晶纤维素压块的机械性能。

The mechanical properties of compacts of microcrystalline cellulose and silicified microcrystalline cellulose.

作者信息

Edge S, Steele D F, Chen A, Tobyn M J, Staniforth J N

机构信息

Department of Pharmacy and Pharmacology, University of Bath, UK.

出版信息

Int J Pharm. 2000 Apr 25;200(1):67-72. doi: 10.1016/s0378-5173(00)00343-4.

DOI:10.1016/s0378-5173(00)00343-4

PMID:10845687

Abstract

The mechanical properties of compacts of unlubricated microcrystalline cellulose and silicified microcrystalline cellulose were evaluated using the diametric tensile test. The results suggested that, under comparable testing conditions, compacts of silicified microcrystalline cellulose exhibited greater strength than those of microcrystalline cellulose. In addition to enhanced strength, silicified microcrystalline cellulose compacts exhibited greater stiffness and required considerably more energy for tensile failure to occur. Comparison of the data with that obtained for a dry blend of silicon dioxide/microcrystalline cellulose suggested that the functionality benefits of silicification were not due to a simple composite material model.

摘要

使用径向拉伸试验评估了未润滑微晶纤维素和硅化微晶纤维素压块的机械性能。结果表明，在可比的测试条件下，硅化微晶纤维素压块比微晶纤维素压块表现出更高的强度。除了强度增强外，硅化微晶纤维素压块还表现出更高的刚度，并且发生拉伸破坏需要相当多的能量。将这些数据与二氧化硅/微晶纤维素干混物的数据进行比较表明，硅化的功能益处并非源于简单的复合材料模型。