单核细胞增生李斯特菌中的一种多药外排转运蛋白。
A multidrug efflux transporter in Listeria monocytogenes.
作者信息
Mata M T, Baquero F, Pérez-Díaz J C
机构信息
Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health, Crta. Colmenar Km 9,1, 28034, Madrid, Spain.
出版信息
FEMS Microbiol Lett. 2000 Jun 15;187(2):185-8. doi: 10.1111/j.1574-6968.2000.tb09158.x.
A chromosomal gene (mdrL) was found in Listeria monocytogenes L028, showing a high degree of similarity with multidrug efflux transporters of the major facilitator superfamily (family 2). An allele-substituted mutant of this gene failed to pump out ethidium bromide and presented lower minimal inhibitory concentrations of macrolides, cefotaxime and heavy metals. This is the first multidrug efflux pump described in Listeria.
在单核细胞增生李斯特菌L028中发现了一个染色体基因（mdrL），它与主要转运体超家族（第2家族）的多药外排转运蛋白具有高度相似性。该基因的等位基因替代突变体无法排出溴化乙锭，并且对大环内酯类、头孢噻肟和重金属的最低抑菌浓度较低。这是在李斯特菌中描述的首个多药外排泵。
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