多层面氧增强磁共振肺成像中信号强度变化的优化与评估

Optimization and evaluation of the signal intensity change in multisection oxygen-enhanced MR lung imaging.

作者信息

Löffler R, Müller C J, Peller M, Penzkofer H, Deimling M, Schwaiblmair M, Scheidler J, Reiser M

机构信息

Department of Diagnostic Radiology, Klinikum Grosshadern, University of Munich, Munich, Germany.

出版信息

Magn Reson Med. 2000 Jun;43(6):860-6. doi: 10.1002/1522-2594(200006)43:6<860::aid-mrm12>3.0.co;2-c.

DOI:10.1002/1522-2594(200006)43:6<860::aid-mrm12>3.0.co;2-c

PMID:10861881

Abstract

The behavior of the signal intensity in MRI of human lungs was investigated during inhalation of pure oxygen. Nine volunteers were examined, five using a breath-hold and four using a non-breath-hold technique. Four coronal slices were acquired in each volunteer using an inversion recovery turbo spin-echo sequence. The inversion time of the sequence was optimized for maximum contrast. Breathing of pure oxygen and room air was alternated in the volunteers. Breath-hold and non-breath-hold cases were compared. Breathing pure oxygen lead to a statistically significant signal intensity increase (up to 18%) compared to breathing room air. In addition, T(1) maps were acquired during breathing 100% oxygen and room air. Inhalation of pure oxygen reduced the mean T(1) time of the lungs from 1280 (+/-85) msec to 1224 (+/-139) msec without breath-hold and from 1219 (+/-176) to 1074 (+/-92) msec with breath-hold. Therefore, an optimized sequence and measurement protocol provided significant signal intensity changes utilizing 100% oxygen. Magn Reson Med 43:860-866, 2000.

摘要

在吸入纯氧过程中，对人体肺部磁共振成像（MRI）的信号强度行为进行了研究。对9名志愿者进行了检查，其中5名采用屏气技术，4名采用非屏气技术。使用反转恢复快速自旋回波序列为每名志愿者采集4个冠状面切片。对序列的反转时间进行了优化以获得最大对比度。让志愿者交替吸入纯氧和室内空气。对屏气和非屏气情况进行了比较。与吸入室内空气相比，吸入纯氧导致信号强度有统计学意义的增加（高达18%）。此外，在吸入100%氧气和室内空气期间采集了T(1)图。吸入纯氧使肺部的平均T(1)时间在非屏气时从1280（±85）毫秒降至1224（±139）毫秒，在屏气时从1219（±176）毫秒降至1074（±92）毫秒。因此，优化的序列和测量方案利用100%氧气可使信号强度发生显著变化。《磁共振医学》43:860 - 866，2000年。