阿尔茨海默病大脑中载脂蛋白E等位基因依赖性抗氧化活性

Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease.

作者信息

Tamaoka A, Miyatake F, Matsuno S, Ishii K, Nagase S, Sahara N, Ono S, Mori H, Wakabayashi K, Tsuji S, Takahashi H, Shoji S

机构信息

Department of Neurology, University of Tsukuba, Ibaraki, Japan.

出版信息

Neurology. 2000 Jun 27;54(12):2319-21. doi: 10.1212/wnl.54.12.2319.

DOI:10.1212/wnl.54.12.2319

PMID:10881261

Abstract

Thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation, were assayed in postmortem brain. Basal TBARS levels were increased and oxidative stimulation produced more TBARS in AD relative to control brains. In addition, apolipoprotein E isoforms showed differing antioxidant activities, with E2 > E3 > E4, suggesting that the lowest antioxidant activity of E4 could contribute to its association with AD.

摘要

硫代巴比妥酸反应性物质（TBARS）是脂质过氧化的一个指标，在死后大脑中进行了测定。与对照大脑相比，阿尔茨海默病（AD）患者的基础TBARS水平升高，氧化刺激产生了更多的TBARS。此外，载脂蛋白E亚型表现出不同的抗氧化活性，即E2 > E3 > E4，这表明E4的最低抗氧化活性可能与其与AD的关联有关。