特定免疫球蛋白G抗体亲和力在免疫功能低下患者再激活型弓形虫病血清学诊断中的应用价值不足。
Lack of utility of specific immunoglobulin G antibody avidity for serodiagnosis of reactivated toxoplasmosis in immunocompromised patients.
作者信息
Mechain B, Garin Y J, Robert-Gangneux F, Dupouy-Camet J, Derouin F
机构信息
Laboratoire de Parasitologie-Mycologie, Hôpital Saint-Louis, 75475 Paris Cedex 10, France.
出版信息
Clin Diagn Lab Immunol. 2000 Jul;7(4):703-5. doi: 10.1128/CDLI.7.4.703-705.2000.
Abstract
The avidities of Toxoplasma-specific immunoglobulin G serum antibodies were measured in immunocompromised patients presenting with cerebral or extracerebral toxoplasmosis and/or serological reactivation. Since avidity remained high and stable in 39 of 40 patients with toxoplasmosis and 27 of 28 patients with serological reactivation, we conclude that this test cannot help diagnose toxoplasmosis in these patients.
摘要
对患有脑型或脑外型弓形虫病和/或血清学复发的免疫功能低下患者检测了弓形虫特异性免疫球蛋白G血清抗体的亲和力。由于40例弓形虫病患者中的39例以及28例血清学复发患者中的27例，其抗体亲和力保持高且稳定，因此我们得出结论，该检测无助于诊断这些患者的弓形虫病。
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本文引用的文献
1
IgG avidity in the serodiagnosis of acute Toxoplasma gondii infection: a multicenter study.
Clin Microbiol Infect. 1996 Aug;2(1):25-29. doi: 10.1111/j.1469-0691.1996.tb00196.x.
2
Incidence and risk factors of toxoplasmosis in a cohort of human immunodeficiency virus-infected patients: 1988-1995. HEMOCO and SEROCO Study Groups.
Clin Infect Dis. 1999 Mar;28(3):575-81. doi: 10.1086/515147.
3
[Property of antibody avidity in the detection of toxoplasmosis seroconversion].
Ann Biol Clin (Paris). 1998 Sep-Oct;56(5):586-9.
4
Estimation of the avidity of immunoglobulin G for routine diagnosis of chronic Toxoplasma gondii infection in pregnant women.
Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):32-6. doi: 10.1007/BF01584360.
5
Improved diagnosis of primary Toxoplasma gondii infection in early pregnancy by determination of antitoxoplasma immunoglobulin G avidity.
J Clin Microbiol. 1997 Aug;35(8):1972-7. doi: 10.1128/jcm.35.8.1972-1977.1997.
6
Predictive value of Toxoplasma gondii antibody titres on the occurrence of toxoplasmic encephalitis in HIV-infected patients. ANRS 005/ACTG 154 Trial Group.
AIDS. 1996 Nov;10(13):1521-7. doi: 10.1097/00002030-199611000-00010.
7
Toxoplasmosis acquired during pregnancy: improved serodiagnosis based on avidity of IgG.
J Infect Dis. 1993 Mar;167(3):691-7. doi: 10.1093/infdis/167.3.691.
8
[Value of the study of IgG avidity for the diagnosis of toxoplasmosis].
Pathol Biol (Paris). 1993 Feb;41(2):155-8.
9
The diagnosis of toxoplasmosis using IgG avidity.
Epidemiol Infect. 1994 Apr;112(2):399-408. doi: 10.1017/s0950268800057812.
10
Primary and reactivated toxoplasma infection in patients with cardiac transplants. Clinical spectrum and problems in diagnosis in a defined population.
Ann Intern Med. 1983 Jul;99(1):27-31. doi: 10.7326/0003-4819-99-1-27.
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