Synthesis and antisecretory activity of 6-substituted 5-cyanomethylimidazo[2,1-b]thiazoles and 2,6-dimethyl-5-hydroxymethylimidazo[2,1-b][1,3,4]thiadiazole.
作者信息
Andreani A, Leoni A, Locatelli A, Morigi R, Rambaldi M, Simon W A, Senn-Bilfinger J
机构信息
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
出版信息
Arzneimittelforschung. 2000 Jun;50(6):550-3. doi: 10.1055/s-0031-1300247.
PMID:10918949
Abstract
The synthesis of imidazo[2,1-b]thiazole and imidazo[2,1-b][1,3,4]thiadiazole derivatives, related to known antiulcer agents, is reported. 5-Cyanomethyl-6-methylimidazo[2,1-b]thiazole showed significant antisecretory activity in the isolated rabbit gastric glands assay.
摘要
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