衰老对女性和男性的球后循环有着不同的影响。

Aging affects the retrobulbar circulation differently in women and men.

作者信息

Harris A, Harris M, Biller J, Garzozi H, Zarfty D, Ciulla T A, Martin B

机构信息

Department of Ophthalmology, Indiana University, School of Medicine, Indianapolis, IN 46202 USA.

出版信息

Arch Ophthalmol. 2000 Aug;118(8):1076-80. doi: 10.1001/archopht.118.8.1076.

DOI:10.1001/archopht.118.8.1076

PMID:10922201

Abstract

BACKGROUND

While aging clearly has protean biological effects on every organ system, the differential effects of aging in women and men in the retrobulbar vasculature, to our knowledge, have never been investigated. Because glaucoma and age-related macular degeneration are closely linked to advanced age, we performed a cross-sectional study using color Doppler imaging of 4 retrobulbar vessels in both healthy women and men.

OBJECTIVE

To define the influence of aging per se on ocular hemodynamics.

METHODS

Women (n = 73) and men (n = 55), aged from 20 to 90 years, free of ocular and systemic disease, and with normal intraocular pressure, were recruited for this study. Postmenopausal women who were not receiving estrogen replacement therapy were also recruited. Studies involved color Doppler imaging analysis of the ophthalmic, central retinal, and nasal and temporal posterior ciliary arteries. Ophthalmic arterial peak systolic and end-diastolic velocities and a Pourcelot resistance index were determined for each vessel.

RESULTS

In both sexes, ophthalmic arterial end-diastolic velocity decreased and the Pourcelot resistance index rose with advancing age (each P<. 001); peak systolic velocity in the ophthalmic vessel was age-independent. In contrast, central retinal arterial flow velocities were unaffected by age in both sexes. In the posterior ciliary arteries, in men, flow velocities and the Pourcelot resistance index were independent of age. However, in women, end-diastolic velocity decreased with age in both the nasal and temporal posterior ciliary vessel (each P<.05); peak systolic velocity was constant; the Pourcelot resistance index in each ciliary artery rose with advancing age (each P<.05).

CONCLUSION

In healthy women and men, aging-induced changes in retrobulbar hemodynamics are comparable to alterations seen in patients with glaucoma or age-related macular degeneration, suggesting that vascular changes with senescence may contribute to increased risk for these diseases in older age. Arch Ophthalmol. 2000;118:1076-1080

摘要

背景

衰老显然对每个器官系统都有多种生物学影响，但据我们所知，衰老对女性和男性球后血管系统的不同影响从未被研究过。由于青光眼和年龄相关性黄斑变性与高龄密切相关，我们进行了一项横断面研究，对健康女性和男性的4条球后血管进行彩色多普勒成像。

目的

确定衰老本身对眼部血流动力学的影响。

方法

招募年龄在20至90岁之间、无眼部和全身疾病且眼压正常的女性（n = 73）和男性（n = 55）参与本研究。未接受雌激素替代疗法的绝经后女性也被招募。研究包括对眼动脉、视网膜中央动脉以及鼻侧和颞侧睫状后动脉进行彩色多普勒成像分析。测定每条血管的眼动脉收缩期峰值速度、舒张末期速度和泊肃叶阻力指数。

结果

在两性中，随着年龄增长，眼动脉舒张末期速度降低，泊肃叶阻力指数升高（均P <.001）；眼动脉的收缩期峰值速度与年龄无关。相比之下，两性的视网膜中央动脉血流速度不受年龄影响。在睫状后动脉中，男性的血流速度和泊肃叶阻力指数与年龄无关。然而，在女性中，鼻侧和颞侧睫状后血管的舒张末期速度均随年龄降低（均P <.05）；收缩期峰值速度恒定；每条睫状动脉的泊肃叶阻力指数随年龄增长而升高（均P <.05）。