Raley J, Geisler J P, Buekers T E, Sorosky J I
Division of Gynecologic Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.
Gynecol Oncol. 2000 Aug;78(2):259-60. doi: 10.1006/gyno.2000.5873.
Docetaxel is a relatively new taxane that has not been associated with significant tissue injury after extravasation. We present a case of a patient who had grade 4 tissue toxicity after extravasation of docetaxel infused through a peripheral intravenous site.
A 71-year-old female was being treated for recurrent ovarian cancer with docetaxel and carboplatin. Shortly after the docetaxel infusion began, she experienced docetaxel extravasation into the dorsum of her left hand. The infusion was halted, and then the administration was continued in a peripheral intravenous site in the other upper extremity. Erythema was noted by the patient on the dorsum of her left hand 6 days after infiltration. The following day, the patient noted severe pain, decreased function, and blistering along with increased erythema. The patient presented to the gynecology oncology clinic 11 days after the extravasation injury occurred. Conservative management was undertaken, and over the next 4 weeks the patient had resolution of the skin changes and full return of function.
Docetaxel can cause significant delayed tissue injury if extravasation occurs.
多西他赛是一种相对较新的紫杉烷类药物，外渗后未发现有明显的组织损伤。我们报告一例通过外周静脉输注多西他赛后发生4级组织毒性的患者。
一名71岁女性因复发性卵巢癌接受多西他赛和卡铂治疗。多西他赛输注开始后不久，她的左手背发生了多西他赛外渗。输注停止，然后在另一侧上肢的外周静脉部位继续给药。浸润6天后患者发现左手背出现红斑。第二天，患者出现严重疼痛、功能减退、水疱以及红斑加重。外渗损伤发生11天后，患者前往妇科肿瘤门诊就诊。采取了保守治疗，在接下来的4周内，患者皮肤变化消退，功能完全恢复。
如果发生多西他赛外渗，可导致严重的延迟性组织损伤。
Zotero 插件