T-cell regulation of peripheral tolerance and immunity: the potential role for Notch signalling.
作者信息
Hoyne G F, Dallman M J, Lamb J R
机构信息
Immunobiology Group, MRC Centre for Inflammation Research and the Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, UK.
出版信息
Immunology. 2000 Jul;100(3):281-8. doi: 10.1046/j.1365-2567.2000.00073.x.
Abstract
Recognition of antigen by T cells in the periphery may lead either to the generation of productive immunity or the induction of tolerance. These two functional outcomes are a consequence of distinct pathways of T-cell differentiation. T cells are selected to become regulatory cells and their function is to maintain homeostasis with the immune system. In this review we discuss the cell-fate decisions that T cells might make allowing them to promote immunity or induce tolerance in the context of the role that Notch signalling may play in this process.
摘要
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