Colović R, Micev M, Zogović S, Colović N, Stojković M, Masirević V
Clinical Centre of Serbia, Institute of Digestive Diseases, Belgrade.
Srp Arh Celok Lek. 2000 Mar-Apr;128(3-4):104-9.
Epithelioid leiomyosarcoma of the stomach is an uncommon tumour, predominantly in old persons. The majority of tumours are small, giant tumours are rare. A tumour is more frequent in the upper part of the stomach. It rarely gives secondary deposits, almost only large ones. In a few big published series of patients, secondary deposit were not found in lymph nodes or other organs. Gastrointestinal bleeding, easy fatigue and pain are the usual symptoms of the disease. Endoscopic and fine needle biopsy was successful in single cases. A limited wedge gastric resection is considered as one of the most appropriate surgical treatments. Major resections are reserved for giant tumours infiltrating surrounding organs, and for recurrencies. Due to rare involvement of lymph nodes, systematic lymph node dissection is not regarded as a necessary procedure. The recurrencies can be successfully removed in a number of cases. Chemo- and radiotherapy are generally regarded as useless. We present a 61-year old male patient who had discomfort in the upper abdomen. CT scan was performed but radiologist missed to diagnose an obvious mass in the upper mid-abdomen. Three years later he came with high temperature and leukocytosis. The preoperative examination showed conflicting results, ultrasonography that the tumour did not belong to the liver but CT scan showed that the tumour arose from the left lobe of the liver. Barium swallow showed signs of external pressure on the stomach from the right toward left and downwards. During the operation, a giant gastric tumour (215 x 139 x 135 mm) originating in the antral part of the small gastric curvature was removed with distal 2/3 of the stomach. Histologic examination showed epithelioid leiomyosarcoma of the stomach with umbilical ulceration. About 50% of the tumour was necrotic. There were no lymph node deposits. Temperature and WBC count dropped to the normal value soon after surgery. The patient stayed symptom-free so far, five months after the operation.
胃上皮样平滑肌肉瘤是一种罕见肿瘤,主要发生于老年人。大多数肿瘤较小,巨大肿瘤罕见。肿瘤多见于胃上部。很少发生继发性转移,几乎仅发生大的转移灶。在已发表的少数大宗病例系列中,未在淋巴结或其他器官发现继发性转移。胃肠道出血、易疲劳和疼痛是该病的常见症状。内镜检查和细针活检仅在个别病例中成功。有限的楔形胃切除术被认为是最合适的手术治疗方法之一。扩大切除术适用于浸润周围器官的巨大肿瘤及复发病例。由于很少累及淋巴结,系统性淋巴结清扫不被视为必要步骤。在一些病例中,复发病灶可成功切除。化疗和放疗一般被认为无效。我们报告一名61岁男性患者,上腹部不适。进行了CT扫描,但放射科医生未诊断出上腹部中部明显肿块。三年后,他因高热和白细胞增多前来就诊。术前检查结果相互矛盾,超声检查显示肿瘤不属于肝脏,但CT扫描显示肿瘤起源于肝左叶。吞钡检查显示胃从右向左向下受到外部压迫的迹象。手术中,切除了起源于胃小弯窦部的巨大胃肿瘤(215×139×135mm)及胃远端2/3。组织学检查显示胃上皮样平滑肌肉瘤伴脐部溃疡形成。肿瘤约50%坏死。无淋巴结转移。术后体温和白细胞计数很快降至正常。术后五个月,患者至今无症状。