泛素生物学：老狗学旧招。

Ubiquitin biology: an old dog learns an old trick.

作者信息

Pickart C M

出版信息

Nat Cell Biol. 2000 Aug;2(8):E139-41. doi: 10.1038/35019610.

DOI:10.1038/35019610

Abstract

Regulated protein degradation in eukaryotes occurs principally through covalent tagging of substrates with ubiquitin, thereby targeting them for destruction by 26S proteasomes. Classical allostery has now been added to the repertoire of mechanisms that can modulate ubiquitin tagging, allowing feed-forward regulation to be achieved through targeted protein destruction.

摘要

真核生物中受调控的蛋白质降解主要通过泛素与底物的共价标记来实现，从而将它们靶向26S蛋白酶体进行降解。经典的变构调节现已被纳入可调节泛素标记的机制库中，使得通过靶向蛋白质降解实现前馈调节成为可能。