来自高氏十字花瓣木的细胞毒性强心苷和抗菌萜类化合物。

Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri.

作者信息

Ankli A, Heilmann J, Heinrich M, Sticher O

机构信息

Department of Applied Bioscience, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zürich.

出版信息

Phytochemistry. 2000 Jun;54(5):531-7. doi: 10.1016/s0031-9422(00)00144-8.

DOI:10.1016/s0031-9422(00)00144-8

PMID:10939358

Abstract

From the methanol extract of the roots of (Crossopetalum gaumeri, four new highly cytotoxic cardenolides, securigenin-3beta-O-beta-6-deoxyguloside (2), 19-hydroxy-sarmentogenin-3beta-O-beta-6-deoxyguloside (4), sarmentogenin-3beta-O-[alpha-allosyl-(1-->4)-beta-6-deoxy alloside] (5), and securigenin-3beta-O-[alpha-allosyl-(1-->4)-beta-6-deoxyal loside] (6) were isolated. The dichloromethane extract afforded the new diterpene 3,15-dihydroxy-18-norabieta-3,8,11,13-tetraene (7) as well as the new triterpene 2,3,7-trihydroxy-6-oxo-1,3,5(10),7-tetraene-24-nor-friedelane-29-o ic acid methylester (11). The new terpenoids lack cytotoxicity and the antibacterial activity is moderate to low.

摘要

从（高氏十字花瓣木）根部的甲醇提取物中，分离出了四种新的具有高细胞毒性的强心苷，即securigenin - 3β - O - β - 6 - 脱氧葡糖苷（2）、19 - 羟基 - 杠柳毒苷元 - 3β - O - β - 6 - 脱氧葡糖苷（4）、杠柳毒苷元 - 3β - O - [α - 阿洛糖基 - (1→4) - β - 6 - 脱氧阿洛糖苷]（5）和securigenin - 3β - O - [α - 阿洛糖基 - (1→4) - β - 6 - 脱氧阿洛糖苷]（6）。二氯甲烷提取物得到了新的二萜3,15 - 二羟基 - 18 - 降松香二烯 - 3,8,11,13 - 四烯（7）以及新的三萜2,3,7 - 三羟基 - 6 - 氧代 - 1,3,5(10),7 - 四烯 - 24 - 降 - 羊毛甾烷 - 29 - 油酸甲酯（11）。这些新的萜类化合物缺乏细胞毒性，抗菌活性为中度至低度。