Seder R A, Hill A V
Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Nature. 2000 Aug 17;406(6797):793-8. doi: 10.1038/35021239.
Vaccines against a variety of infectious diseases represent one of the great triumphs of medicine. The immune correlates of protection induced by most current vaccines seem to be mediated by long-lived humoral immune responses. By contrast, there are no currently available vaccines that are uniformly effective for diseases such as HIV, malaria and tuberculosis, in which the cellular immune response might be crucial in mediating protection. Here we examine the mechanisms by which long-lived cellular immune responses are generated and maintained in vivo. We then discuss current approaches for vaccination against diseases in which cellular immune responses are important for protection.
针对多种传染病的疫苗是医学领域的重大成就之一。目前大多数疫苗诱导产生的保护性免疫相关因素似乎是由持久的体液免疫反应介导的。相比之下，目前尚无对如HIV、疟疾和结核病等疾病均有效的疫苗，而在这些疾病中细胞免疫反应对介导保护作用可能至关重要。在此，我们研究了体内产生并维持持久细胞免疫反应的机制。然后我们讨论了针对细胞免疫反应对保护作用很重要的疾病的当前疫苗接种方法。
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