L-MYC和谷胱甘肽S-转移酶M1（GSTM1）基因多态性与胶质瘤不良临床参数相关。

L-MYC and GSTM1 polymorphisms are associated with unfavourable clinical parameters of gliomas.

作者信息

Kondratieva T V, Imyanitov E N, Togo A V, Zaitseva O A, Yatsuk O S, Romanenko S M, Bersnev V P, Hanson K P

机构信息

Dept. of Pediatric Surgery, L.A. Polenov Neurosurgery Institute, St. Petersburg, Russia.

出版信息

J Exp Clin Cancer Res. 2000 Jun;19(2):197-200.

PMID:10965818

Abstract

L-MYC and GSTM1 genotypes were analysed in glioma patients (GP) and healthy donors (HD). None of these genes appeared to influence the risk of this disease, however both polymorphisms correlated with unfavourable clinical parameters of gliomas. In particular, S allele of the L-MYC was overrepresented in the relapsed patients (P < 0.05), and GSTM1-null genotype was associated with the advanced tumour grade (P < 0.05). Patients, but not donors, demonstrated frequent combination of SS L-MYC homozygosity with GSTM1(-) variant (P < 0.01 ), as well as a correlation between LL L-MYC homozygosity and GSTM1 (+) genotype (P < 0.05).

摘要

在胶质瘤患者（GP）和健康供体（HD）中分析了L-MYC和GSTM1基因的基因型。这些基因似乎均未影响该疾病的风险，然而，这两种多态性均与胶质瘤的不良临床参数相关。具体而言，L-MYC的S等位基因在复发患者中过度表达（P < 0.05），GSTM1无效基因型与肿瘤高级别相关（P < 0.05）。患者（而非供体）表现出SS型L-MYC纯合性与GSTM1（-）变体的频繁组合（P < 0.01），以及LL型L-MYC纯合性与GSTM1（+）基因型之间的相关性（P < 0.05）。