南方红豆杉种子中的紫杉烷二萜类化合物。

Taxane diterpenoids from seeds of Taxus mairei.

作者信息

Shen Y C, Chen C Y, Hung M C

机构信息

Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.

出版信息

Chem Pharm Bull (Tokyo). 2000 Sep;48(9):1344-6. doi: 10.1248/cpb.48.1344.

DOI:10.1248/cpb.48.1344

PMID:10993234

Abstract

A new 2(3-->20) abeotaxane, taxumairone A (1), and a new cis-p-coumaroyl myo-inositol have been isolated from the seeds of Taxus mairei in addition to taxin B (2), taxinine A, taxuspine X, decinnamoyltaxinine E, 5alpha-cinnamoyloxy-9alpha,10beta,13alpha- triacetoxy-taxa-4(20)11-diene and 5alpha-cinnamoyloxy-2alpha,9alpha,10beta,+ ++13alpha-tetraacetoxy-taxa-4(20)11-diene. The structure of 1 was determined by 2D-NMR spectral analysis and chemical correlation with taxin B (2). Compound 1 exhibited potent cytotoxicity against human colon carcinoma cells with an ED50 of 0.1 microg/ml.

摘要

除了从红豆杉种子中分离出的三尖杉宁碱B（2）、紫杉宁A、紫杉刺X、去肉桂酰三尖杉宁碱E、5α-肉桂酰氧基-9α,10β,13α-三乙酰氧基-紫杉-4(20),11-二烯和5α-肉桂酰氧基-2α,9α,10β,13α-四乙酰氧基-紫杉-4(20),11-二烯外，还从南方红豆杉种子中分离出一种新的2(3→20) 阿巴紫杉烷，即南方红豆杉素A（1）和一种新的顺式对香豆酰肌醇。通过二维核磁共振光谱分析和与三尖杉宁碱B（2）的化学关联确定了1的结构。化合物1对人结肠癌细胞表现出较强的细胞毒性，半数有效剂量（ED50）为0.1微克/毫升。