Theodorou D A, Velmahos G C, Souter I, Chan L S, Vassiliu P, Tatevossian R, Murray J A, Demetriades D
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Am Surg. 2000 Sep;66(9):809-12.
Trauma in pregnancy places the mother and fetus at risk. The objective of this study is to identify risk factors independently associated with acute termination of pregnancy and/or fetal mortality after trauma. The medical and trauma registry records of 80 injured pregnant patients were reviewed. Data were collected and then analyzed by univariate and multivariate analysis. Three patients died (3.7%), 23 had the pregnancy acutely terminated (30%), and 14 suffered fetal death (17.5%). The only independent risk factors for fetal mortality were an Injury Severity Score (ISS) > or =9 and a nonviable pregnancy (<23 weeks). The combination of both risk factors increased the likelihood of fetal mortality by fivefold over that of patients without either risk factor. Maternal hemodynamic parameters did not predict fetal loss. Two patients lost their fetuses despite insignificant trauma (ISS = 1) and normal hemodynamic parameters, whereas eight delivered normal babies despite major trauma (ISS > or = 16). Hemodynamic stability on admission does not predict fetal mortality. Although the presence of moderate to severe injuries (ISS > or = 9) increases the likelihood of fetal mortality, this complication may occur even with insignificant trauma. Close maternal and fetal monitoring is justified, regardless of maternal hemodynamic presentation or severity of injury.
孕期创伤会使母亲和胎儿面临风险。本研究的目的是确定与创伤后妊娠急性终止和/或胎儿死亡独立相关的风险因素。回顾了80例受伤孕妇的医疗和创伤登记记录。收集数据后进行单因素和多因素分析。3例患者死亡(3.7%),23例妊娠急性终止(30%),14例胎儿死亡(17.5%)。胎儿死亡的唯一独立风险因素是损伤严重度评分(ISS)≥9分和不可存活妊娠(<23周)。这两个风险因素同时存在时,胎儿死亡的可能性比无任何一个风险因素的患者增加了五倍。母亲的血流动力学参数不能预测胎儿丢失。2例患者尽管创伤轻微(ISS = 1)且血流动力学参数正常,但仍失去了胎儿,而8例患者尽管创伤严重(ISS≥16),却产下了正常婴儿。入院时的血流动力学稳定性不能预测胎儿死亡。尽管中度至重度损伤(ISS≥9)会增加胎儿死亡的可能性,但即使创伤轻微也可能发生这种并发症。无论母亲的血流动力学表现或损伤严重程度如何,对母亲和胎儿进行密切监测都是合理的。