Rabsch W, Hargis B M, Tsolis R M, Kingsley R A, Hinz K H, Tschäpe H, Bäumler A J
Robert Koch Institute, Wernigerode, Germany.
Emerg Infect Dis. 2000 Sep-Oct;6(5):443-8. doi: 10.3201/eid0605.000501.
Salmonella Enteritidis emerged as a major egg-associated pathogen in the late 20th century. Epidemiologic data from England, Wales, and the United States indicate that S. Enteritidis filled the ecologic niche vacated by eradication of S. Gallinarum from poultry, leading to an epidemic increase in human infections. We tested this hypothesis by retrospective analysis of epidemiologic surveys in Germany and demonstrated that the number of human S. Enteritidis cases is inversely related to the prevalence of S. Gallinarum in poultry. Mathematical models combining epidemiology with population biology suggest that S. Gallinarum competitively excluded S. Enteritidis from poultry flocks early in the 20th century.
肠炎沙门氏菌在20世纪后期成为一种主要的与蛋类相关的病原体。来自英格兰、威尔士和美国的流行病学数据表明,肠炎沙门氏菌填补了因在家禽中根除鸡白痢沙门氏菌而空出的生态位,导致人类感染病例呈流行趋势增加。我们通过对德国的流行病学调查进行回顾性分析来检验这一假设,并证明人类肠炎沙门氏菌病例数与家禽中鸡白痢沙门氏菌的流行率呈负相关。将流行病学与种群生物学相结合的数学模型表明,在20世纪早期,鸡白痢沙门氏菌在家禽群体中竞争性地排除了肠炎沙门氏菌。