Li X, Zhang L, Zhang W, Hall S E, Tam J P
Sphinx Pharmaceuticals, A Division of Eli Lilly and Company, Cambridge, Massachusetts 02139, USA.
Org Lett. 2000 Oct 5;2(20):3075-8. doi: 10.1021/ol006209z.
A solid-phase method for the synthesis of 1,2,3, 4-tetrahydro-beta-carboline-containing peptidomimetics has been developed. The key step in the strategy is the Pictet-Spengler condensation of a resin-bound tryptophan-containing fragment with an Fmoc-amino aldehyde.
已开发出一种用于合成含1,2,3,4-四氢-β-咔啉的拟肽的固相方法。该策略的关键步骤是将树脂结合的含色氨酸片段与Fmoc-氨基醛进行Pictet-Spengler缩合反应。
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