酰胺型REM树脂上叔胺的固相合成：格氏试剂和金属氢化物兼容树脂

Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins.

作者信息

Plater M J, Murdoch A M, Morphy J R, Rankovic Z, Rees D C

机构信息

Department of Chemistry, University of Aberdeen, Scotland, UK.

出版信息

J Comb Chem. 2000 Sep-Oct;2(5):508-12. doi: 10.1021/cc000023+.

DOI:10.1021/cc000023+

PMID:11029176

Abstract

Four new amide REM resins (AM REM 2-5) are described, and their use is illustrated for the synthesis of tertiary amines 6-9 and 13-16. Amide REM resins 4 and 5, which have a phenyl ring attached to the amide nitrogen, are found to give superior product yields and purities, and the resins are stable to a wider range of reagents and conditions compared to REM resin 1.

摘要

本文描述了四种新型酰胺型REM树脂（AM REM 2 - 5），并举例说明了它们在叔胺6 - 9和13 - 16合成中的应用。发现酰胺型REM树脂4和5的酰胺氮上连接有苯环，其产物收率和纯度更高，并且与REM树脂1相比，这些树脂对更广泛的试剂和条件具有稳定性。