Yamaura K, Higashi M, Akiyoshi K, Itonaga Y, Inoue H, Takahashi S
Department of Anaesthesiology and Critical Care Medicine, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Eur J Anaesthesiol. 2000 Nov;17(11):704-8. doi: 10.1046/j.1365-2346.2000.00759.x.
We present a case of pulmonary embolism that occurred during the injection of lipiodol during transcatheter arterial chemoembolization under general anaesthesia. A 7-year-old child suffering from a large hepatoblastoma was admitted for arterial chemoembolization and carcinostatic administration. Pulmonary embolism due to lipiodol during arterial chemoembolization was evident by a sudden fall in oxyhaemoglobin saturation from 100 to 90%. This was associated with a spread of lipiodol into both lungs, particularly the middle lung zones and detected by chest fluoroscopy. Arterial blood gases returned to normal values 1 day later but pulmonary infiltration persisted for 7 days before final clearance. Pulmonary embolism caused by lipiodol during arterial chemoembolization is infrequent, but such a complication could prove fatal. Understanding the risk of pulmonary embolism in patients receiving lipiodol, during and after arterial chemoembolization, and late onset pulmonary injury is important and a close follow-up for several days after arterial chemoembolization is advisable.
我们报告一例在全身麻醉下经导管动脉化疗栓塞术注射碘油过程中发生肺栓塞的病例。一名7岁患有巨大肝母细胞瘤的儿童因动脉化疗栓塞和抗癌药物给药入院。动脉化疗栓塞期间碘油导致的肺栓塞表现为氧合血红蛋白饱和度突然从100%降至90%。这与碘油扩散至双肺,尤其是肺中叶有关,并通过胸部荧光透视检测到。1天后动脉血气恢复正常,但肺部浸润持续7天后方最终消散。动脉化疗栓塞期间碘油引起的肺栓塞并不常见,但这种并发症可能是致命的。了解接受碘油治疗的患者在动脉化疗栓塞期间及之后发生肺栓塞的风险以及迟发性肺损伤很重要,动脉化疗栓塞后进行数天的密切随访是可取的。