放线菌素D和雌二醇对新生期雄激素化雌性大鼠促黄体生成素释放激素反应的影响。

Effect of actinomycin D and estradiol on the response to LH-releasing hormone in neonatally androgenized femal rats.

作者信息

Debeljuk L, Rettori V, Rozados R V, Vélez C V

出版信息

Proc Soc Exp Biol Med. 1975 Oct;150(1):229-31. doi: 10.3181/00379727-150-39008.

Abstract

The effect of estradiol, actinomycin D, or both, on pituitary response to LH-RH was studied in 6-month-old female rats which had been injected with testosterone propionate on the 2nd day of life. Estradiol significantly augmented the pituitary response to LH-RH. Actinomycin D did not significantly modify basal serum LH levels and pituitary response to LH-RH but did significantly inhibit the augmenting effect of estradiol on such a response.

摘要

在出生后第2天注射丙酸睾酮的6月龄雌性大鼠中，研究了雌二醇、放线菌素D或二者对垂体对促黄体激素释放激素（LH-RH）反应的影响。雌二醇显著增强了垂体对LH-RH的反应。放线菌素D并未显著改变基础血清促黄体生成素（LH）水平以及垂体对LH-RH的反应，但确实显著抑制了雌二醇对这种反应的增强作用。