Al-Bozom I A, El-Faqih S R, Hassan S H, El-Tiraifi A E, Talic R F
Departments of Pathology, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia.
Arch Pathol Lab Med. 2000 Oct;124(10):1525-8. doi: 10.5858/2000-124-1525-GCTOTA.
We report a case of testicular granulosa cell tumor of the adult type in a 48-year-old man. Microscopically, the tumor consisted of round to ovoid cells with grooved nuclei that were arranged in several patterns, including microfollicular, macrofollicular, insular, trabecular, gyriform, solid, and pseudosarcomatous. These cells demonstrated strong immunopositivity with MIC2 (O13) antibody, vimentin, and smooth muscle actin and focal positivity with cytokeratin. Although this type of sex cord-stromal tumor is relatively common in the ovaries, it is still extremely unusual in the testis, and it probably represents the rarest type of testicular sex cord-stromal tumor.
我们报告一例48岁男性的成人型睾丸颗粒细胞瘤。显微镜下,肿瘤由圆形至卵圆形细胞组成,细胞核有沟,排列成多种模式,包括微滤泡状、大滤泡状、岛状、小梁状、脑回状、实性和假肉瘤样。这些细胞对MIC2(O13)抗体、波形蛋白和平滑肌肌动蛋白呈强免疫阳性,对细胞角蛋白呈局灶性阳性。尽管这种类型的性索间质肿瘤在卵巢中相对常见,但在睾丸中仍然极为罕见,它可能是最罕见的睾丸性索间质肿瘤类型。