[Pathological study of en bloc breast sections in papillomatosis and its malignant transformation].

OBJECTIVE

To investigate the characteristics of breast papillomatosis, its malignant transformation and relation with main ductal papilloma.

METHODS

A histopathological study by en bloc breast subserial sections was performed on 14 cases of highly proliferative papillomatosis and 22 cases of carcinoma arising from the highly proliferative papillomatosis.

RESULTS

The two types of lesions were widely scattered over the sections, covering more than two quadrants in 71.4% (10/14) and 63.3% (14/22) of the breast, respectively. Crisscross and histological transition of the two lesions were observed frequently in the sections of carcinoma arising from the highly proliferative papillomatosis. These two kinds of lesion often coexisted with main ductal papilloma.

CONCLUSION

Papillomatosis is a breast precancerous lesion and it may have similar pathogenetic mechanism as main ductal papilloma.