Schuckit M A, Smith T L, Radziminski S, Heyneman E K
Department of Psychiatry, VA San Diego Healthcare System, CA 92161-2002, USA.
Am J Psychiatry. 2000 Nov;157(11):1881-3. doi: 10.1176/appi.ajp.157.11.1881.
People with alcoholic relatives have high rates of alcohol abuse and dependence as adults, but their patterns of problems earlier in life are less clear. Many studies have not controlled for parental disorders other than alcoholism or for parents' socioeconomic status and general life functioning. The authors' goal was to conduct a study controlling for such factors.
Personal structured interviews and a behavioral checklist were administered to the parents of 162 children 7 years old or older whose fathers had participated in the 15-year follow-up of 453 sons of alcoholics with no history of antisocial personality disorder and sons of nonalcoholic comparison subjects originally selected from a university population.
There was no significant relationship between a family history of alcoholism and childhood diagnoses of conduct, oppositional, or attention deficit disorders or with behavioral checklist summary scores. However, children with alcoholic relatives apparently have a slightly higher risk for drug abuse or dependence than those without alcoholic relatives.
Once familial antisocial disorders and familial socioeconomic status are controlled for, a family history of alcoholism does not appear to relate to childhood externalizing disorders.
有酗酒亲属的人成年后酒精滥用和酒精依赖的发生率很高,但他们早年的问题模式尚不太明确。许多研究并未对除酗酒以外的父母疾病或父母的社会经济地位及总体生活功能进行控制。作者的目标是开展一项对这些因素进行控制的研究。
对162名7岁及以上儿童的父母进行了个人结构化访谈和行为清单调查,这些儿童的父亲参与了对453名无反社会人格障碍病史的酗酒者之子以及最初从大学人群中选取的非酗酒对照对象之子的15年随访。
酗酒家族史与童年期品行、对立违抗或注意力缺陷障碍的诊断或行为清单总分之间无显著关系。然而,有酗酒亲属的儿童显然比没有酗酒亲属的儿童有略高的药物滥用或药物依赖风险。
一旦控制了家族性反社会障碍和家族社会经济地位,酗酒家族史似乎与童年期外化性障碍无关。