Shibata K, Osawa M, Iwata M
Department of Neurology, Neurological Institute, Tokyo Women's Medical University, Japan.
Acta Neurol Scand. 2000 Oct;102(4):230-5. doi: 10.1034/j.1600-0404.2000.102004230.x.
To investigate the correlation of the cerebral white matter hyperintensities (WMH) on MRI, and latency and amplitude of visual evoked potentials (VEPs) in elderly subjects.
Pattern VEP (PVEP) and flash VEP (FVEP) were recorded in 25 patients with WMH consisting of 12 patients with frontal dominant WMH (FMH) and 13 patients with occipital dominant WMH (OMH) and 25 patients with basal ganglionic hyperintensities (BGH).
In WMHs, there were significantly larger P100 and P2 amplitudes than in BGHs and controls. Regarding the distribution of WMH, OMH showed significantly larger P100 amplitudes than FMH. In OMH in males, there was significantly prolonged P100 latency compared with females, and in females, there were significantly larger P100 and P2 amplitudes compared with males.
Appropriate clinical values in VEP should take into consideration WMH in addition to gender and age-related changes.
研究老年受试者磁共振成像（MRI）上脑白质高信号（WMH）与视觉诱发电位（VEP）潜伏期及波幅的相关性。
对25例WMH患者进行图形视觉诱发电位（PVEP）和闪光视觉诱发电位（FVEP）检测，其中包括12例额叶为主的WMH（FMH）患者、13例枕叶为主的WMH（OMH）患者以及25例基底节高信号（BGH）患者。
在WMH患者中，P100和P2波幅明显大于BGH患者和对照组。关于WMH的分布，OMH患者的P100波幅明显大于FMH患者。在男性OMH患者中，P100潜伏期明显长于女性；在女性患者中，P100和P2波幅明显大于男性。
VEP的临床评估除考虑性别和年龄相关变化外，还应考虑WMH。
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