阿尔茨海默病中8,12-异前列腺素F2α-VI水平升高：脂质过氧化非侵入性指标与疾病严重程度的相关性。

Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity.

作者信息

Praticò D, Clark C M, Lee V M, Trojanowski J Q, Rokach J, FitzGerald G A

机构信息

Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104, USA.

出版信息

Ann Neurol. 2000 Nov;48(5):809-12.

PMID:11079549

Abstract

The isoprostane 8,12-iso-iPF2alpha-VI is a sensitive and specific marker of in vivo lipid peroxidation. We found elevated levels in the urine, blood, and cerebrospinal fluid of patients with Alzheimer's disease (AD) that correlated with measures of cognitive and functional impairment, established biomarkers of AD pathology (cerebrospinal fluid tau and amyloid) and the number of apolipoprotein E epsilon4 alleles. These results suggest that 8,12-iso-iPF2alpha-VI is a useful biomarker of oxidative damage in AD.

摘要

异前列腺素8,12-异-iPF2α-VI是体内脂质过氧化反应的一种敏感且特异的标志物。我们发现，阿尔茨海默病（AD）患者的尿液、血液和脑脊液中该标志物水平升高，且与认知和功能损害程度、已确定的AD病理学生物标志物（脑脊液tau蛋白和淀粉样蛋白）以及载脂蛋白Eε4等位基因数量相关。这些结果表明，8,12-异-iPF2α-VI是AD氧化损伤的一种有用的生物标志物。