Lau E C, Cooper C, Lam D, Chan V N, Tsang K K, Sham A
Department of Community and Family Medicine, The Chinese University of Hong Kong.
Am J Epidemiol. 2000 Nov 1;152(9):855-62. doi: 10.1093/aje/152.9.855.
In 1998, a case-control study was conducted in Hong Kong on hospital patients with osteoarthritis of the hip (n = 138) and osteoarthritis of the knee (n = 658). Age- and sex-matched controls were recruited consecutively from general practice clinics in the same region. The following three risk factors were found to be associated with osteoarthritis of both the hip and the knee: first, a history of joint injury: for osteoarthritis of the hip, the odds ratio = 25.1 (95% confidence interval (CI): 3.5, 181) in men and 43.3 (95% CI: 11.7, 161) in women; for osteoarthritis of the knee, the odds ratio = 12.1 (95% CI: 3.4, 42.5) in men and 7.6 (95% CI: 3.8, 15.2) in women; second, climbing stairs frequently: for osteoarthritis of the hip, the odds ratio = 12.5 (95% CI: 1.5, 104.3) in men and 2.3 (95% CI: 0.6, 8.1) in women; for osteoarthritis of the knee, the odds ratio = 2.5 (95% CI: 1.0, 6.4) in men and 5.1 (95% CI: 2.5, 10.2) in women; third, lifting heavy weight frequently: for osteoarthritis of the hip, the odds ratio = 3.1 (95% CI: 0.7, 14.3) in men and 2.4 (95% CI: 1.1, 5.3) in women; for osteoarthritis of the knee, the odds ratio = 5.4 (95% CI: 2.4, 12.4) in men and 2.0 (95% CI: 1.2, 3.1) in women. In addition, subjects whose height and weight were in the highest quartile were at increased risk of osteoarthritis of the hip and knee, respectively (p < 0.05).
1998年，在香港针对髋骨关节炎患者（n = 138）和膝骨关节炎患者（n = 658）开展了一项病例对照研究。从同一地区的普通诊所中连续招募年龄和性别匹配的对照。发现以下三个风险因素与髋骨关节炎和膝骨关节炎均相关：第一，关节损伤史：对于髋骨关节炎，男性的优势比= 25.1（95%置信区间（CI）：3.5，181），女性为43.3（95% CI：11.7，161）；对于膝骨关节炎，男性的优势比= 12.1（95% CI：3.4，42.5），女性为7.6（95% CI：3.8，15.2）；第二，频繁爬楼梯：对于髋骨关节炎，男性的优势比= 12.5（95% CI：1.5，104.3），女性为2.3（95% CI：0.6，8.1）；对于膝骨关节炎，男性的优势比= 2.5（95% CI：1.0，6.4），女性为5.1（95% CI：2.5，10.2）；第三，频繁搬运重物：对于髋骨关节炎，男性的优势比= 3.1（95% CI：0.7，14.3），女性为2.4（95% CI：1.1，5.3）；对于膝骨关节炎，男性的优势比= 5.4（95% CI：2.4，12.4），女性为2.0（95% CI：1.2，3.1）。此外，身高和体重处于最高四分位数的受试者分别患髋骨关节炎和膝骨关节炎的风险增加（p < 0.05）。
