Cytotoxic constituents of Polyalthia longifolia var. pendula.

作者信息

Chen C Y, Chang F R, Shih Y C, Hsieh T J, Chia Y C, Tseng H Y, Chen H C, Chen S J, Hsu M C, Wu Y C

机构信息

Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

出版信息

J Nat Prod. 2000 Nov;63(11):1475-8. doi: 10.1021/np000176e.

A new halimane diterpene, 3beta,5beta, 16alpha-trihydroxyhalima-13(14)-en-15,16-olide (1), and a new oxoprotoberberine alkaloid, (-)-8-oxopolyalthiaine (2), along with 20 known compounds, were isolated from a methanolic extract of Polyalthia longifolia var. pendula. The structures of compounds 1 and 2 were established by spectroscopic analysis. Several of these compounds were evaluated for cytotoxicity toward a small panel of human cell lines.