“必需性”测试：寻找新的抗菌靶点

"Essentiality" Testing: Looking for New Antimicrobial Targets.

作者信息

Knowles D, Patou G

机构信息

Ladywell House, Boroughbridge, North Yorkshire, YO51 9EB, UK.

出版信息

Curr Infect Dis Rep. 1999 Dec;1(5):488-494. doi: 10.1007/s11908-999-0063-x.

DOI:10.1007/s11908-999-0063-x

PMID:11095828

Abstract

After a gap of some 30 years, the prospect of finding completely new agents with which to combat infectious disease is promising. New discovery approaches based on the application of genomics and associated technologies are leading to the identification of genes essential for bacterial viability and pathogenesis. This article reviews the current status of the search for new antimicrobial targets and points to future developments and issues.

摘要

在间隔约30年后，寻找全新的抗传染病药物的前景十分广阔。基于基因组学及相关技术应用的新发现方法，正促使人们识别出细菌生存能力和致病性所必需的基因。本文综述了寻找新抗菌靶点的现状，并指出了未来的发展方向和问题。