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[利什曼病]

[Leishmaniasis].

作者信息

Kemp M, Theander T G

机构信息

Klinisk mikrobiologisk afdeling, H:S Hvidovre Hospital.

出版信息

Ugeskr Laeger. 2000 Nov 13;162(46):6203-7.

Abstract

Leishmania parasites are obligate intracellular protozoa, that produce clinical pictures, ranging from localised, self-healing ulcers to systemic, lethal diseases. The diseases caused by the parasites can be divided into cutaneous, mucocutaneous, and visceral leishmaniasis. Recovery from the infection often leaves lifelong immunity. Leishmaniasis may occur in individuals who have been to the Mediterranean countries, the countries on the Horn of Africa, the Arabian Peninsula, parts of Asia, and South and Central America. Co-infection of Leishmania parasites and HIV is a special problem. Leishmaniasis can be treated with pentavalent compounds of antimony, but other drugs, including amphotericin B, are also affective.

摘要

利什曼原虫是专性细胞内原生动物,可引发多种临床表现,从局部自限性溃疡到全身性致命疾病。由这些寄生虫引起的疾病可分为皮肤利什曼病、黏膜皮肤利什曼病和内脏利什曼病。感染康复后通常会产生终身免疫力。利什曼病可能发生在去过地中海国家、非洲之角国家、阿拉伯半岛、亚洲部分地区以及南美洲和中美洲的人身上。利什曼原虫与艾滋病毒的合并感染是一个特殊问题。利什曼病可用五价锑化合物治疗,但其他药物,包括两性霉素B,也有效。

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