儿童肿瘤的产前流行病学

Prenatal epidemiology of pediatric tumors.

作者信息

Ross J A, Swensen A R

机构信息

Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota Medical School, Box 422, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA.

出版信息

Curr Oncol Rep. 2000 May;2(3):234-41. doi: 10.1007/s11912-000-0073-1.

DOI:10.1007/s11912-000-0073-1

PMID:11122848

Abstract

With the exception of a small percentage of cases attributable to hereditary cancer syndromes (eg, familial retinoblastoma) or genetic syndromes (Down syndrome), the etiology of most childhood cancers is unknown. Recent epidemiologic studies have focused on the prenatal period and have investigated potential associations with parental age, cigarette smoking, birth weight of the child, parental occupational exposures, and specific environmental exposures. The following challenges lie ahead for future epidemiologic studies of childhood cancer: 1) improvement of diagnostic classification; 2) improved methods for exposure assessment; 3) evaluation of data from molecular biology to generate biologically derived hypotheses; and 4) incorporation of markers of genetic susceptibility when feasible.

摘要

除了一小部分归因于遗传性癌症综合征（如家族性视网膜母细胞瘤）或遗传综合征（唐氏综合征）的病例外，大多数儿童癌症的病因尚不清楚。最近的流行病学研究集中在孕期，并调查了与父母年龄、吸烟、孩子出生体重、父母职业暴露以及特定环境暴露之间的潜在关联。儿童癌症未来的流行病学研究面临以下挑战：1）改进诊断分类；2）改进暴露评估方法；3）评估分子生物学数据以产生基于生物学的假设；4）在可行的情况下纳入遗传易感性标记。