Gross P L, Aird W C
Department of Medicine and Molecular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
Semin Thromb Hemost. 2000;26(5):463-78. doi: 10.1055/s-2000-13202.
Thrombosis reflects an imbalance between procoagulant and anticoagulant mechanisms. In some cases, thrombotic lesions are precipitated by gross changes in blood flow, vascular wall integrity, or systemic levels of coagulation factors. In other cases, thrombosis is induced by functional changes within the endothelium. Endothelial cells express a wide variety of factors that contribute to hemostasis, including procoagulants, anticoagulants, cell adhesion molecules, vasomotor substances, and cell survival signals. Because the endothelium displays a remarkable diversity of structure and function, the relative contribution of any one of these factors to the hemostatic balance varies between different vascular beds. In this review, we emphasize the heterogeneous nature of endothelial cell function. We then examine the role of endothelial diversity in modulating the phenotypic expression of thrombotic disorders.
血栓形成反映了促凝和抗凝机制之间的失衡。在某些情况下，血栓性病变是由血流、血管壁完整性或凝血因子的全身水平的显著变化所引发的。在其他情况下，血栓形成是由内皮细胞内的功能变化所诱导的。内皮细胞表达多种有助于止血的因子，包括促凝剂、抗凝剂、细胞粘附分子、血管舒缩物质和细胞存活信号。由于内皮细胞在结构和功能上表现出显著的多样性，这些因子中的任何一种对止血平衡的相对贡献在不同的血管床之间有所不同。在这篇综述中，我们强调了内皮细胞功能的异质性。然后，我们研究了内皮细胞多样性在调节血栓性疾病表型表达中的作用。
