抗胆碱酯酶药物诱发的重症肌无力合并冠状动脉痉挛性心绞痛——病例报告

Coronary spastic angina induced by anticholinesterase medication for myasthenia gravis--a case report.

作者信息

Suzuki M, Yoshii T, Ohtsuka T, Sasaki O, Hara Y, Okura T, Shigematsu Y, Hamada M, Hiwada K

机构信息

Second Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun, Japan.

出版信息

Angiology. 2000 Dec;51(12):1031-4. doi: 10.1177/000331970005101209.

DOI:10.1177/000331970005101209

PMID:11132996

Abstract

Myasthenia gravis (MG) is characterized by weakness of skeletal muscles because of a decrease in the number of available acetylcholine receptors at neuromuscular junctions. Anticholinesterase medication is widely used to treat MG, but muscarinic side effects sometimes appear and limit the drug usage. To their knowledge, the authors present the first case of coronary spastic angina quite possibly induced by anticholinesterase medication to treat MG. The appearance of coronary spastic angina in the present case is likely mediated through the increase of acethylcholine by anticholinesterase medication.

摘要

重症肌无力（MG）的特征是骨骼肌无力，这是由于神经肌肉接头处可用的乙酰胆碱受体数量减少所致。抗胆碱酯酶药物被广泛用于治疗MG，但有时会出现毒蕈碱样副作用并限制了该药物的使用。据作者所知，本文首次报道了1例很可能由治疗MG的抗胆碱酯酶药物诱发的冠状动脉痉挛性心绞痛。本例冠状动脉痉挛性心绞痛的出现可能是由抗胆碱酯酶药物使乙酰胆碱增加所介导的。