Borger M A, Rao V, Weisel R D, Floh A A, Cohen G, Feindel C M, Scully H E, Mickleborough L L, Yau T M
Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, Ontario, Canada.
J Thorac Cardiovasc Surg. 2001 Jan;121(1):83-90. doi: 10.1067/mtc.2001.111382.
To determine the effects of patent or diseased aorta-coronary bypass grafts and retrograde cardioplegia on mortality during reoperative coronary bypass surgery.
We conducted a retrospective review of prospectively gathered data, supplemented by systematic chart review, of all patients (n = 744) undergoing reoperative coronary bypass surgery at our institution between 1990 and 1997. Independent predictors of survival were determined by stepwise logistic regression analysis.
At least one patent or stenosed graft to the left anterior descending artery was present in 50% of patients, to the circumflex territory in 27% of patients, and to the right coronary artery territory in 33% of patients. The previous left anterior descending graft was a saphenous vein in 82% and a left internal thoracic artery in 18% of patients. In-hospital mortality occurred in 42 (5.6%) patients. Patent or diseased grafts of any coronary artery territory did not significantly increase the risk of mortality. Retrograde cardioplegia use increased in more recent years, was more frequent in patients with stenosed grafts, and was associated with improved survival. Independent predictors of mortality were as follows (with odds ratios and 95% confidence intervals in parentheses): failure to use retrograde cardioplegia (odds ratio 2.81; 1.28-6.20), New York Heart Association class (odds ratio 2.69; 1.25-5.81), peripheral vascular disease (odds ratio 2.60; 1.25-5.41), and left ventricular grade (2.07; 1.31-3.27).
In this series, patent or stenosed grafts were not associated with an increased risk of mortality during reoperative coronary bypass surgery, possibly because of increased use of retrograde cardioplegia in this patient group. We strongly recommend the routine use of retrograde cardioplegia during redo coronary bypass surgery.
确定通畅或病变的主动脉-冠状动脉旁路移植血管以及逆行性心脏停搏对再次冠状动脉旁路移植手术死亡率的影响。
我们对1990年至1997年间在本机构接受再次冠状动脉旁路移植手术的所有患者(n = 744)进行了回顾性研究,前瞻性收集的数据辅以系统的病历审查。通过逐步逻辑回归分析确定生存的独立预测因素。
50%的患者至少有一根通畅或狭窄的移植血管通向左前降支动脉,27%的患者通向回旋支区域,33%的患者通向右冠状动脉区域。既往左前降支移植血管中,82%为大隐静脉,18%为左内乳动脉。42例(5.6%)患者发生院内死亡。任何冠状动脉区域的通畅或病变移植血管均未显著增加死亡风险。近年来逆行性心脏停搏的使用增加,在移植血管狭窄的患者中更频繁,且与生存率提高相关。死亡的独立预测因素如下(括号内为比值比和95%置信区间):未使用逆行性心脏停搏(比值比2.81;1.28 - 6.20)、纽约心脏协会心功能分级(比值比2.69;1.25 - 5.81)、外周血管疾病(比值比2.60;1.25 - 5.41)和左心室分级(2.07;1.31 - 3.27)。
在本系列研究中,通畅或狭窄的移植血管与再次冠状动脉旁路移植手术期间死亡风险增加无关,可能是因为该患者群体中逆行性心脏停搏的使用增加。我们强烈建议在再次冠状动脉旁路移植手术中常规使用逆行性心脏停搏。