Montecino-Rodriguez E, Leathers H, Dorshkind K
Department of Pathology and Laboratory Medicine and the Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90095-1732, USA.
Nat Immunol. 2001 Jan;2(1):83-8. doi: 10.1038/83210.
According to the current model of adult hematopoiesis, differentiation of pluripotential hematopoietic stem cells into common myeloid- and lymphoid-committed progenitors establishes an early separation between the myeloid and lymphoid lineages. This report describes a rare and previously unidentified CD45R-CD19+ B cell progenitor population in postnatal bone marrow that can also generate macrophages. In addition to the definition of this B-lineage intermediate, the data indicate that a developmental relationship between the B and macrophage lineages is retained during postnatal hematopoiesis.
根据目前的成人造血模型，多能造血干细胞分化为常见的髓系和淋巴系定向祖细胞，在髓系和淋巴系之间建立了早期分离。本报告描述了一种罕见且此前未被识别的产后骨髓中CD45R-CD19+B细胞祖细胞群体，该群体也能产生巨噬细胞。除了对这种B系中间体的定义外，数据表明，产后造血过程中B系和巨噬细胞系之间的发育关系得以保留。
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